Current Publications associated with Max Planck Florida Institute

  1. Montesinos, M., Dong, W., Goff, K., Das, B., Guerrero-Given, D., Schmalzigaug, R., Premont, RT., Satterfield, R., Kamasawa, N., Young, SM, Jr. Presynaptic Deletion of GIT Proteins Results in Increased Synaptic Strength at a Mammalian Central Synapse. Neuron. Volume 88, Issue 5, p918–925, 2 December 2015
  2. Chen, Z., Das B., Nakamura, Y., DiGregorio, D., Young, SM Jr. (2015) Ca2+ Channel to Synaptic Vesicle Distance Accounts for the Readily Releasable Pool Kinetics at a Functionally Mature Auditory Synapse. J Neurosci. 35(5):2083-2100

  3. Maltecca F, Baseggio E, Consolato F, Mazza D, Podini P, Young SM, Jr., Drago I, Bahr BA, Puliti A, Codazzi F, Quattrini A, Casari G (2015) Purkinje neuron Ca2+ influx reduction rescues ataxia in SCA28 model. The Journal of Clinical Investigation 125(1):263–274. doi:10.1172/JCI74770

  4. Tong H, Kopp-Scheinpflug C, Pilati N, Robinson SW, Sinclair JL, Steinert JR, Barnes-Davies M, Allfree R, Grubb BD, Young SM Jr, Forsythe ID. Protection from Noise-Induced Hearing Loss by Kv2.2 Potassium Currents in the Central Medial Olivocochlear System. J Neurosci. 2013 May 22;33(21):9113-9121.

  5. Zuxin Chen, Benjamin Cooper, Stefan Kalla, Frederique Varoqueaux, and Samuel M. Young, Jr. The Munc13 Proteins Differentially Regulate Readily Releasable Pool Dynamics and Calcium-Dependent Recovery at a Central Synapse. The Journal of Neuroscience, 8 May 2013, 33(19):8336-8351; doi:10.1523/JNEUROSCI.5128-12.2013

  6. Monica S. Montesinos, Zuxin Chen, and Samuel M. Young, Jr. pUNISHER: A high level expression cassette for use with recombinant viral vectors for rapid and long term in vivo neuronal expression in the CNS. J Neurophysiol. 106:3230-3244. (2011)

  7. Dusonchet, J., Kochubey, O., Stafa K., Young, S.M. Jr., Zufferey, R., Moore, D.J., Schneider, B.L., Aebischer, P. A Rat Model of Progressive Nigral Neurodegeneration Induced by the Parkinson's Disease-Associated G2019S Mutation in LRRK2. J Neurosci. 31(3):907-12. (2011)

Previous Publications

  1. Kawabe, H., Neeb, A., Dimova, K., Young, S.M. Jr., Takeda, M., Katsurabayashi, S., Mitkovski, M., Malakhova, O.A., Zhang, D., Umikawa, M., Kariya, K., Goebbels, S., Nave, K., Rosenmund, C., Jahn, O., Rhee, J.S., and Brose, N. Regulation of Rap2A by Nedd4-1 Controls Dendrite Development in Cortical Neurons. Neuron. 65(3):358-72. (2010)

  2. Young, S.M. Jr. and Neher, E. Synaptotagmin has an essential function in synaptic vesicle positioning for synchronous release in addition to its role as a calcium sensor. Neuron. 63(4):482-496. (2009)

  3. Schikorski, T., Young, S.M. Jr., Hu, Y. Horseradish peroxidase cDNA as a marker for electron microscopy in neurons. J Neurosci Methods. 165(2):210-5. (2007)

  4. Young, S.M. Jr. Proteolysis of SNARE proteins alters facilitation and depression in a specific way. PNAS. 102(7):2614-9. (2005)

  5. McCarty, D.M., Young, S.M. Jr., and Samulski, R.J. Integration of Adeno-Associated Virus. (invited) Annu Rev Genet. 38:819-45. (2004)

  6. Weitzman, M.D., Young, S.M. Jr., Cathomen, T., and Samulski, R.J. Targeted integration by adeno-associated virus. Methods Mol Med. 76201-19. (2003)

  7. Young, S.M. Jr., and Samulski, R.J. Adeno-associated virus (AAV) site-specific recombination does not require a Rep-depedent origin of replication within the AAV terminal repeat. PNAS. 98(24), 13525-13530. (2001)

  8. Young, S.M. Jr., McCarty, D.M., Natalya Degtyareva, and Samulski, R.J. Roles of Adeno-Associated Virus Rep Protein and Human Chromosome 19 in Site-Specific Recombination. Journal of Virology. 74(9)3953-3966. (2000)

  9. Young, S.M. Jr., Xiao, W., and Samulski, R.J. Site specific targeting of DNA plasmids to chromosome 19 using AAV Cis and Trans sequences. Gene Targeting Vector Protocols Methods in Molecular Biology, Editor. E.B. Kmiec, Humana Press, Totowa, NJ, 2000. Methods in Molecular Biology. 133:111-26. (2000)

  10. Gavin, D.K., Young, S.M. Jr., Xiao, W., Temple, B., Abernathy, C.R., Pereira, D.J., Muzyczka, N., and Samulski, R.J. Charge-to-Alanine Mutagenesis of the Adeno-Associated Virus Type 2 Rep 78/78 proteins yields temperature-sensitive and magnesium-dependent variants. Journal of Virology. 73(11)9433-9445. (1999)

  11. Notterman, D., Young, S.M. Jr., Wainger, B., Levine, A.J. Prevention of mammalian DNA reduplication, following the release from the mitotic spindle checkpoint, requires p53 protein, but not p53-mediated transcriptional activity. Oncogene. 17, 2743-2751. (1998)


Samuel M. Young, Jr., Ph.D
Max Planck Research Group Leader
Molecular Mechanisms of Synaptic Function
One Max Planck Way
Jupiter, FL 33458

(561) 972-9402 (office)
(561) 972-9403 (lab)

Fax: (561) 972-9001


Post Doc Candidate